In an effort to improve student retention and success in the Organic Chemistry course, a blend learning format has been implemented. A number of pedagogical strategies are utilized synergistically to promote learning and knowledge retention in the course. While students read course material and review online lectures outside of class, the in class period focuses on promoting students’ mastery of course content and developing their cognitive ability related to chemical concepts. This is primarily done through collaborative learning exercises called ChemDrills. The distribution of activities reflected in the ChemDrills are as follows: Analogies (5%), inquiry-based learning/critical thinking (45%), computational models (8%), and traditional drill/practice problem sets (73%). Assessment of learning outcomes is enhanced through the use of technology and include online blogs, online quizzes, in class quizzes, survey, and peer-observations. This presentation will provide a rationale and an overview of the approach. In addition, the success of the strategies will be presented as a summary of student’s perceived learning gains in comparison to students’ self- and peer reported behaviors.