Overview of Projects
Cancer Drug Design and Synthesis
Benzimidazoles have vast biological activity and medicinal utility. Our work involves the synthesis and design of novel di-substituted benzimidazoles and the evaluation of their therapeutic potential against cancers which disproportionately impact African Americans. With this, a primary focus of the work is the elucidation of the structure-activity relationship of the molecules and the mechanism by which they inhibit the development and progression of cancers. The work utilizes methods related to computer-aided drug design and microwave assisted organic synthesis.
Funding for this work was received through the National Institute of Health/National Center on Minority Health and Health Disparities: Research Infrastructure in Minority Institutions Award No. 5p20md000215-07002 – Sub-project.
Teaching and Learning in Chemistry
A number of pedagogical innovations are being utilized synergistically to develop a comprehensive model that leads to improved student performance in the major. The project aims to produce novel tools and adopt proven methods for engaging students in the mastery of STEM concepts and promoting knowledge retention. At the center of the project is cohort building, peer mentorship and tutoring, and blended classroom activities that should lead to improved student support system for success throughout the curriculum. It is envisioned that students exposed to these interventions in the first and second year will develop learning strategies that translate into their success in upper level courses and their retention in the major.
Funding for this work was received through the National Science Foundation Award Histrorically Black Colleges and Universities grant No. HRD-1332575 and National Institute of Health Planning Grants for the NIH Building Infrastructure Leading to Diversity (BUILD) Initiative (P20) Award No. 1P20MD008719-01.